In:
Journal of Surgical Oncology, Wiley, Vol. 121, No. 5 ( 2020-04), p. 893-900
Abstract:
Hepatic metastases are a major cause of death in patients with colorectal cancer. A comprehensive assessment of the prognostic factors associated with long‐term survival could improve patient selection for surgical approaches and decrease morbidity and futile locoregional treatments. Methods We performed a retrospective analysis of patients who underwent hepatectomy for colorectal liver metastases at a single center from 2000 to 2012. Results To identify factors associated with 5‐ and 10‐year overall (OS) and disease‐free survival (DFS), we analyzed 280 patients and 150 patients in the 5‐ and 10‐year cohorts, respectively. Only seven relapses occurred after 5 years of follow‐up, and no relapses occurred after 10 years. Multivariable analysis indicated that bilobar disease and extra‐hepatic disease before hepatectomy were independent 5‐ and 10‐year predictors of OS, and major postoperative complications predicted OS in the 5‐year survival cohort only. Our analysis indicated that prognostic factors associated with DFS included some confounders and was therefore inconclusive. Conclusions Taken together, our results suggest that the predictors of 5‐ and 10‐year OS rates of colorectal cancer patients with hepatic metastases are similar, differing only by postoperative complications that influenced exclusively 5‐year survival. Since no relapse occurred 10 years after hepatic resection, oncological remission is likely.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1475314-5