In:
Journal of Ultrasound in Medicine, Wiley, Vol. 41, No. 3 ( 2022-03), p. 749-762
Abstract:
Percutaneous transendocardial injections of therapeutic agents into the myocardium may not always be effective. We used an animal model for assessing the efficacy of the injections using linoleic acid as a testing agent. Efficacious delivery into the myocardium of a beating heart was indicated by rapidly developed local myocardial necrosis and wall motion abnormalities using echocardiography. We employed this experimental model to test our innovative technology, an acoustically active injection catheter. The Doppler ultrasound‐guided acoustically active injection catheter effectively delivers the substance to the myocardium but needs further technical improvements to minimize an unwanted systemic distribution of the agent.
Type of Medium:
Online Resource
ISSN:
0278-4297
,
1550-9613
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2067124-6