In:
Macromolecular Bioscience, Wiley, Vol. 9, No. 12 ( 2009-12-08), p. 1202-1210
Abstract:
A temperature‐sensitive block copolymer (PAAm‐ b ‐PNIPAAm‐Te) with a glutathione peroxidase‐like active site was synthesized via ATRP. As a new glutathione peroxidase (GPx) mimic, it displays typical saturation kinetic behaviors and high catalytic activity. More importantly, the catalytic activity of the polymer can be well modulated by changing the temperature. The experiments proved that a change in the self‐assembly structure of the polymer plays a key role for the modulation of catalytic activity. As a contrast, another block copolymer, PAAm‐Te‐ b ‐PNIPAAm, was synthesized. In comparison with PAAm‐ b ‐PNIPAAm‐Te, the different temperature dependent catalytic behavior seen further indicates that the micellar structure plays an important role in modulating the catalytic activity of the smart enzyme model. magnified image
Type of Medium:
Online Resource
ISSN:
1616-5187
,
1616-5195
DOI:
10.1002/mabi.200900208
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2039130-4
SSG:
12