In:
Macromolecular Bioscience, Wiley, Vol. 12, No. 12 ( 2012-12), p. 1714-1720
Kurzfassung:
A novel actively targeted polymer carrier for anticancer drugs based on an N ‐(2‐hydroxypropyl)methacrylamide copolymer (PHPMA) is proposed. An oligopeptide sequence GE7, attached to the polymer, is a specific ligand for the EGF receptor overexpressed on most tumor cells. Co‐attachment of selected chemotherapeutics will therefore lead to formation of tumor‐specific polymer therapeutics, further enhanced by the EPR effect. FACS measurements prove elevated binding activity of the fluorescently labeled PHPMA/GE7 conjugate in EGFR‐rich cells (FaDu, MCF‐7), compared to conjugates of scrambled peptides. Cell lines with low EGFR level (SW620, B16F10) bind the GE7 conjugate significantly less. magnified image
Materialart:
Online-Ressource
ISSN:
1616-5187
,
1616-5195
DOI:
10.1002/mabi.201200270
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2012
ZDB Id:
2039130-4
SSG:
12
