In:
Macromolecular Chemistry and Physics, Wiley, Vol. 212, No. 17 ( 2011-09), p. 1918-1924
Abstract:
The synthesis of linear polyethyleneimine (LPEI) by acidic hydrolysis of poly(2‐ethyl‐2‐oxazoline) is studied and optimized to reach the highest degree of hydrolysis within the shortest time range using a microwave synthesizer. In addition, the purification procedure is significantly improved; the fast batch processing combined with an excellent control of the actual heating time represents a well‐suited alternative to the conventional synthesis on the way to “pharmagrade” PEI. The developed protocol for the preparation of methyl and proton‐initiated LPEIs shows a high reproducibility, and the identity and purity of the LPEIs is proven by means of 1 H NMR and IR spectroscopy as well as MALDI‐TOF‐ and ESI‐Q‐TOF‐MS. magnified image
Type of Medium:
Online Resource
ISSN:
1022-1352
,
1521-3935
DOI:
10.1002/macp.v212.17
DOI:
10.1002/macp.201100190
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1475026-0