In:
Macromolecular Rapid Communications, Wiley, Vol. 42, No. 13 ( 2021-07)
Abstract:
The incorporation of an amino group into a bifunctional initiator for the cationic ring‐opening polymerization (CROP) is achieved in a two‐step reaction. Detailed kinetic studies using 2‐ethyl‐2‐oxazoline demonstrate the initiators’ eligibility for the CROP yielding well‐defined polymers featuring molar masses of about 2000 g mol –1 . Deprotection of the phthalimide moiety subsequent to polymerization enables the introduction of a cyclooctyne group in central position of the polymer which is further exploited in a strain‐promoted alkyne‐azide click reaction (SpAAC) with a Fmoc‐protected azido lysine representing a commonly used binding motif for site specific polymer–protein/peptide conjugation. In‐depth characterization via electrospray ionization mass spectrometry (ESI) confirms the success of all post polymerization modification steps.
Type of Medium:
Online Resource
ISSN:
1022-1336
,
1521-3927
DOI:
10.1002/marc.202100132
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
1475027-2