In:
Macromolecular Symposia, Wiley, Vol. 224, No. 1 ( 2005-04), p. 263-274
Abstract:
The effects of heat treatment of chitosan film on the proliferation of vascular cells were examined in vitro . Chitosan film was heat treated at 110 °C in vacuo for 1∼3 days. Heat treatment slightly improved the hydrophilicity of chitosan, although the cross‐linking of chitosan took place after heat treatment. Chitosan films were cytocompatible toward smooth muscle cells (SMCs) and human dermal microvascular endothelial cells (HDMECs) before and after heat treatment of chitosan. In particular, the heat treated chitosan supported the proliferation of both vascular cell types for one day. The growth of HDMECs was greater than that of SMCs on heat treated chitosan film for one day. Heat treated chitosan has intrinsic biological activity which could contribute to a retardation of SMC growth relative to HDMECs.
Type of Medium:
Online Resource
ISSN:
1022-1360
,
1521-3900
DOI:
10.1002/masy.200550623
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2038549-3