In:
Movement Disorders Clinical Practice, Wiley, Vol. 10, No. 7 ( 2023-07), p. 1107-1113
Abstract:
To date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias. Objectives To compare demographic data and clinical features in patients with adult‐onset acquired and idiopathic dystonias. Methods Patients were identified from among those included in the Italian Dystonia Registry, a multicenter Italian dataset of patients with adult‐onset dystonia. Study population included 116 patients with adult‐onset acquired dystonia and 651 patients with isolated adult‐onset idiopathic dystonia. Results Comparison of acquired and idiopathic dystonia revealed differences in the body distribution of dystonia, with oromandibular dystonia, limb and trunk dystonia being more frequent in patients with acquired dystonia. The acquired dystonia group was also characterized by lower age at dystonia onset, greater tendency to spread, lower frequency of head tremor, sensory trick and eye symptoms, and similar frequency of neck pain associated with CD and family history of dystonia/tremor. Conclusions The clinical phenomenology of dystonia may differ between acquired and idiopathic dystonia, particularly with regard to the body localization of dystonia and the tendency to spread. This dissimilarity raises the possibility of pathophysiological differences between etiologic categories.
Type of Medium:
Online Resource
ISSN:
2330-1619
,
2330-1619
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2772809-2