In:
Movement Disorders, Wiley, Vol. 38, No. 4 ( 2023-04), p. 692-697
Kurzfassung:
Subthalamic nucleus (STN) beta (13 ‐ 35 Hz) activity is a biomarker reflecting motor state in Parkinson's disease (PD). Adaptive deep brain stimulation (DBS) aims to use beta activity for therapeutic adjustments, but many aspects of beta activity in real‐life situations are unknown. Objective The aim was to investigate Christmas‐related influences on beta activity in PD. Methods Differences in Christmas Day to nonfestive daily averages in chronic biomarker recordings in 4 PD patients with a sensing‐enabled STN DBS implant were retrospectively analyzed. Sweet‐spot and whole‐brain network connectomic analyses were performed. Results Beta activity was significantly reduced on Christmas Eve in all patients (4.00–9.00 p.m.: −12.30 ± 10.78%, P = 0.015). A sweet spot in the dorsolateral STN connected recording sites to motor, premotor, and supplementary motor cortices. Conclusions We demonstrate that festive events can reduce beta biomarker activity. We conclude that circadian and holiday‐related changes should be considered when tailoring adaptive DBS algorithms to patient demands. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Materialart:
Online-Ressource
ISSN:
0885-3185
,
1531-8257
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2023
ZDB Id:
2041249-6