In:
mLife, Wiley, Vol. 2, No. 1 ( 2023-03), p. 11-27
Abstract:
We show that the Kinase, putative Endopeptidase, and Other Proteins of Small size (KEOPS) complex in archaea contains five subunits just as that in eukaryotes. We identified that one of the two Pcc1 paralogs in archaea is a functional homolog of the eukaryotic Gon7. Strong evidence supports the fact that KEOPS in thermophilic archaea plays an essential role in a fundamental cellular process, presumably homologous recombination (HR), independent of the t 6 A modification level. We propose a link between t 6 A modification and HR as well as telomere maintenance of KEOPS. The study provides insights into the structure and evolution of the KEOPS and will be helpful for further understanding the functional mechanism of the evolutionarily conserved complex.
Type of Medium:
Online Resource
ISSN:
2770-100X
,
2770-100X
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
3120417-X