In:
Magnetic Resonance in Medicine, Wiley, Vol. 34, No. 3 ( 1995-09), p. 368-377
Kurzfassung:
To determine the relationship between reductions in the apparent diffusion coefficient of water (ADC) and in cerebral blood flow (CBF) during focal ischemia, we used diffusion‐weighted magnetic resonance (D‐MR) imaging and autoradiographic CBF analysis to examine rats subjected to 30 or 90 min of permanent middle cerebral artery (MCA) occlusion. In the 30‐min occlusion group ( n = 10), the area with substantially reduced ADC (15% or more below the contralateral level [ADC 15 ]) corresponded best to the area with CBF below 25 ml/100 g/min and was significantly smaller than the area with CBF below 50 ml/100 g/min (CBF 50 ), a level associated with reduced protein synthesis and delayed necrosis (40 ± 13% versus 74 ± 8% of the ischemic hemisphere; P 〈 0.0001). In the 90‐min occlusion group ( n = 6), the ADC 15 area corresponded best to the CBF 30 to CBF 35 area and was again significantly smaller than the CBF 50 area (54 ± 13% versus 73 ± 20%, P 〈 0.05). Thus, the area of substantially reduced ADC at 30 and 90 min represents only 53% and 74%, respectively, of the tissue at risk for infarction. These findings indicate a potential limitation in using early D‐MR imaging to predict stroke outcome.
Materialart:
Online-Ressource
ISSN:
0740-3194
,
1522-2594
DOI:
10.1002/mrm.1910340314
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1995
ZDB Id:
1493786-4