In:
Magnetic Resonance in Medicine, Wiley, Vol. 84, No. 6 ( 2020-12), p. 3206-3222
Kurzfassung:
Quantitative Susceptibility Mapping (QSM) is an emerging technique sensitive to disease‐related changes including oxygenation. It is extensively used in brain studies and has increasing clinical applications outside the brain. Here we present the first MRI acquisition protocol and QSM pipeline optimized for the head‐and‐neck region together with a repeatability analysis performed in healthy volunteers. Methods We investigated both the intrasession and the intersession repeatability of the optimized method in 10 subjects. We also implemented two, Tikhonov‐regularisation‐based susceptibility calculation techniques that were found to have higher contrast‐to‐noise than existing methods in the head‐and‐neck region. Repeatability was evaluated by calculating the distributions of susceptibility differences between repeated scans and the corresponding minimum detectable effect sizes (MDEs). Results Deep brain regions had higher QSM repeatability than neck regions. As expected, intrasession repeatability was generally better than intersession repeatability. Susceptibility maps calculated using projection onto dipole fields for background field removal were more repeatable than using the Laplacian boundary value method in the head‐and‐neck region. Small (short‐axis diameter 〈 5 mm) lymph nodes had the lowest repeatability (MDE = 0.27 ppm) as imperfect segmentation included some of the surrounding paramagnetic fatty fascia, highlighting the importance of accurate region delineation. MDEs in the larger lymph nodes (0.16 ppm), submandibular glands (0.10 ppm), and especially the parotid glands (0.06 ppm) were much lower, comparable to those of the brain regions. Conclusions The high repeatability of the acquisition and pipeline optimized for QSM will facilitate clinical studies in the head‐and‐neck region.
Materialart:
Online-Ressource
ISSN:
0740-3194
,
1522-2594
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2020
ZDB Id:
1493786-4
