In:
Muscle & Nerve, Wiley, Vol. 57, No. 1 ( 2018-01), p. 54-60
Abstract:
Electrical impedance myography (EIM) is a noninvasive electrophysiological technique that characterizes muscle properties through bioimpedance. We compared EIM measurements to function, strength, and disease severity in a population with congenital muscular dystrophy (CMD). Methods Forty‐one patients with CMD, either collagen 6 related disorders (COL6‐RD; n = 21) or laminin α‐2‐related disorders (LAMA2‐RD; n = 20), and 21 healthy pediatric controls underwent 2 yearly EIM exams. In the CMD cohorts, EIM was compared with functional and strength measurements. Results Both CMD cohorts exhibited change over time and had correlation with disease severity. The 50‐kH Z phase correlated well with function and strength in the COL6‐RD cohort but not in the LAMA2‐RD cohort. Discussion EIM is a potentially useful measure in clinical studies with CMD because of its sensitivity to change over a 1‐year period and correlation with disease severity. For COL6‐RD, there were also functional and strength correlations. Muscle Nerve 57 : 54–60, 2018
Type of Medium:
Online Resource
ISSN:
0148-639X
,
1097-4598
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1476641-3
SSG:
12