In:
Obesity, Wiley, Vol. 22, No. 4 ( 2014-04), p. 1157-1164
Abstract:
The GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) consortium is described, along with heritability estimates and genetic and environmental correlations of insulin sensitivity and metabolic clearance rate of insulin (MCRI). Methods GUARDIAN is comprised of seven cohorts, consisting of 4,336 Mexican‐American individuals in 1,346 pedigrees. Insulin sensitivity ( S I ), MCRI, and acute insulin response (AIRg) were measured by frequently sampled intravenous glucose tolerance test in four cohorts. Insulin sensitivity ( M , M / I ) and MCRI were measured by hyperinsulinemic‐euglycemic clamp in three cohorts. Heritability and genetic and environmental correlations were estimated within the family cohorts (totaling 3,925 individuals) using variance components. Results Across studies, age, and gender‐adjusted heritability of insulin sensitivity ( S I , M , M / I ) ranged from 0.23 to 0.48 and of MCRI from 0.35 to 0.73. The ranges for the genetic correlations were 0.91 to 0.93 between S I and MCRI; and −0.57 to −0.59 for AIRg and MCRI (all P 〈 0.0001). The ranges for the environmental correlations were 0.54 to 0.74 for S I and MCRI (all P 〈 0.0001); and −0.16 to −0.36 for AIRg and MCRI ( P 〈 0.0001‐0.06). Conclusions These data support a strong familial basis for insulin sensitivity and MCRI in Mexican Americans. The strong genetic correlations between MCRI and S I suggest common genetic determinants.
Type of Medium:
Online Resource
ISSN:
1930-7381
,
1930-739X
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2027211-X