In:
Obesity, Wiley, Vol. 24, No. 10 ( 2016-10), p. 2038-2041
Abstract:
Since angiopoietin‐2 (Ang‐2) levels strongly correlate with cardiovascular mortality and subclinical cardiovascular disease, it was hypothesized that levels of Ang‐2 and its soluble receptor (sTie‐2) were associated with the metabolic syndrome (MetS) and individual MetS components. Methods Within the population‐based Study of Health in Pomerania, two sets of analyses were performed. First, Ang‐2 and sTie‐2 were related to the prevalence of MetS and its components cross‐sectionally ( n = 3,205). Second, the association between baseline Ang‐2 and sTie‐2 and incident MetS or longitudinal changes in its components in 1,295 individuals was investigated. Results High Ang‐2 levels (90th percentile), compared with low Ang‐2 levels (10th percentile), were positively associated with MetS (OR: 1.78) and with the following MetS criteria: increased triglycerides, lower HDL cholesterol, and higher non‐fasting glucose. Furthermore, high sTie‐2 levels (90th percentile), compared with low levels (10th percentile), were positively related to MetS (OR: 1.58) and most of its components. However, Ang‐2 and sTie‐2 levels were not associated with incident MetS or longitudinal change in components of MetS. Conclusions Ang‐2 and sTie‐2 levels were cross‐sectionally associated with MetS and several of its components. However, Ang‐2 and sTie‐2 levels were not associated with incident MetS or changes in individual MetS components during follow‐up.
Type of Medium:
Online Resource
ISSN:
1930-7381
,
1930-739X
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2027211-X