In:
Otolaryngology–Head and Neck Surgery, Wiley
Abstract:
There is a link between laryngopharyngeal reflux (LPR) and the formation of benign vocal fold lesions (BVFLs). However, previous studies have mainly focused on LPR suggested by symptoms and signs, rather than objectively diagnosed LPR via pharyngeal pH monitoring. We, therefore, conducted a Meta‐analysis to evaluate the association between pharyngeal pH monitoring diagnosed LPR and the odds of BVFLs. Data Sources Relevant observational studies were identified by searching PubMed, Embase, Cochrane Library, and Web of Science. Review Methods We evaluated between‐study heterogeneity using the Cochrane Q test and estimated the I 2 statistic. Random‐effects models were used when significant heterogeneity was observed; otherwise, fixed‐effects models were used. Results Thirteen datasets from 9 studies were included. Among them, 493 were diagnosed with LPR and 344 had BVFLs. LPR was related to a higher odds of BVFLs (odds ratio: 3.26, 95% confidence interval: 1.84‐5.76, P 〈 .001) with moderate heterogeneity ( P for Cochrane Q test = .006, I 2 = 57%). Subgroup analyses showed that the association was similar in studies with only pharyngeal pH monitoring (Restech), with double‐probe or 3‐site pH monitoring, and with 24‐hour multichannel intraluminal impedance‐pH monitoring ( P for subgroup difference = .15). In addition, subgroup analysis showed consistent results in studies from Asia and Europe ( P for subgroup analysis = .12), and the association seemed to be consistent for vocal Reinke's edema, nodules, and polyps ( P for subgroup difference = .09). Conclusion Pharyngeal pH monitoring diagnosed LPR is associated with the formation of BVFLs.
Type of Medium:
Online Resource
ISSN:
0194-5998
,
1097-6817
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2008453-5
