In:
Pediatric Blood & Cancer, Wiley, Vol. 61, No. 11 ( 2014-11), p. 2101-2103
Abstract:
Hyperferritinemia is a hallmark of hemophagocytic lymphohistiocytosis (HLH). In the HLH‐2004 criteria, a ferritin value 〉 500 µg/L is considered positive. However, this level was not determined based on evidence. We compared 123 patients with HLH and 320 patients with other hyperferritinemic conditions, calculated a receiver‐operating characteristic, and determined sensitivity and specificity for different values. At 2,000 µg/L a trade‐off is reached with sensitivity at 70% and specificity at 68%. If familial HLH and virus‐associated acquired HLH are analyzed separately, sensitivity and specificity are similar for this level. The results may guide a potential modification of the current HLH criteria. Pediatr Blood Cancer 2014;61:2101–2103. © 2014 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1545-5009
,
1545-5017
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2131448-2
detail.hit.zdb_id:
2130978-4