In:
Pediatric Blood & Cancer, Wiley, Vol. 68, No. 3 ( 2021-03)
Abstract:
The use of radiotherapy as bridging therapy to chimeric antigen receptor T‐cell therapy (CAR‐T) in pre‐B acute lymphoblastic leukemia (B‐ALL) has been minimally explored. Here, we present a boy with B‐ALL who relapsed after allogeneic bone marrow transplant with disseminated disease, including significant symptomatic cardiovascular and gastrointestinal (GI) involvement. The cardiac and GI leukemic infiltrates were successfully treated with bridging radiation therapy (BRT) prior to CAR‐T infusion. Using this approach, he successfully tolerated CAR‐T with no evidence of disease or sequelae on 3‐month follow‐up. This is the first reported case of safe and effective delivery of cardiac BRT in B‐ALL.
Type of Medium:
Online Resource
ISSN:
1545-5009
,
1545-5017
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2130978-4