In:
Prenatal Diagnosis, Wiley, Vol. 40, No. 8 ( 2020-07), p. 949-957
Abstract:
The objective of this study was to assess whether the laterality of congenital diaphragmatic hernia (CDH) was a prognostic factor for neonatal survival. Methods This was a cohort study using the French national database of the Reference Center for Diaphragmatic Hernias. The principal endpoint was survival after hospitalization in intensive care. We made a comparative study between right CDH and left CDH by univariate and multivariate analysis. Terminations and stillbirths were excluded from analyses of neonatal outcomes. Results A total of 506 CDH were included with 67 (13%) right CDH and 439 left CDH (87%). Rate of survival was 49% for right CDH and 74% for left CDH ( P 〈 .01). Multivariate analysis showed two factors significantly associated with mortality: thoracic herniation of liver (OR 2.27; IC 95% [1.07‐4.76]; P = .03) and lung‐to‐head‐ratio over under expected (OR 2.99; IC 95% [1.41‐6.36]; P 〈 .01). Side of CDH was not significantly associated with mortality (OR 1.87; IC 95% [0.61‐5.51], P = .26). Conclusion Rate of right CDH mortality is more important than left CDH. Nevertheless after adjusting for lung‐to‐head‐ratio and thoracic herniation of liver, right CDH does not have a higher risk of mortality than left CDH.
Type of Medium:
Online Resource
ISSN:
0197-3851
,
1097-0223
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1491217-X