In:
Prenatal Diagnosis, Wiley, Vol. 42, No. 6 ( 2022-05), p. 753-761
Abstract:
What's already known about this topic? Clinically actionable secondary findings may be identified when clinical exome sequencing is performed. Reporting of secondary findings in the prenatal and pediatric settings is ethically challenging; the American College of Medical Genetics & Genomics recommends that this information be offered in the pediatric setting. There is no professional guidance and limited information about patient preferences surrounding secondary findings when exome sequencing is performed in the prenatal setting. What does this study add? A majority of families undergoing exome sequencing in both the pediatric and prenatal settings request the reporting of secondary findings. Frequency of requesting secondary findings was similar among families undergoing prenatal and pediatric exome sequencing. Frequency of requesting secondary findings was similar among families undergoing prenatal exome sequencing with ongoing pregnancies and after pregnancy termination or loss.
Type of Medium:
Online Resource
ISSN:
0197-3851
,
1097-0223
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
1491217-X
