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A rapid and quantitative mass spectrometry method for determining the concentration of acylcarnitines and aminoacids in amniotic fluid

Braida, Laura ; Crovella, Sergio ; Boniotto, Michele ; [et al.]

Wiley ; 2001

In: Prenatal Diagnosis Vol. 21, No. 7 ( 2001-07), p. 543-546

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In: Prenatal Diagnosis, Wiley, Vol. 21, No. 7 ( 2001-07), p. 543-546

Abstract: We describe a quantitative, rapid, sensitive and reproducible tandem mass spectrometry (MSMS) method for the one‐step detection of aminoacid (AAs) and acylcarnitine (ACs) concentrations in amniotic fluid. This technology is quicker and more sensitive than other methods used to date since it is possible to determine very low AA and AC concentrations in samples simultaneously in a single run. The high degree of automation allows a large number of pregnancies to be screened for metabolic defects in a very short time. Copyright © 2001 John Wiley & Sons, Ltd.

Type of Medium: Online Resource

ISSN: 0197-3851 , 1097-0223

URL: Issue

URL: Article

DOI: 10.1002/pd.v21:7

DOI: 10.1002/pd.93

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 2001

detail.hit.zdb_id: 1491217-X