In:
Practical Diabetes, Wiley, Vol. 35, No. 3 ( 2018-05), p. 90-
Abstract:
Several studies have suggested an association between iron deficiency anaemia and higher HbA 1c levels, but the results are conflicting and the matter is under debate. We conducted a retrospective case‐control study to investigate both the effects of iron deficiency and the reduction of haemoglobin level on HbA 1c measurement in subjects with iron deficiency anaemia. Laboratory data were collected from a sample of subjects consecutively assessed from 1990–2016 in the Italian Hospital of Desio, Lombardy. All non‐pregnant subjects aged over 12 years with one HbA 1c measurement, a complete blood count, fasting blood glucose, and ferritin values during the same blood collection were enrolled. A total of 2625 subjects met the study criteria. In all, 109 individuals were diagnosed as affected by iron deficiency anaemia, while 2516 had normal iron and haemoglobin values. The adjusted means of HbA 1c were significantly higher in subjects with iron deficiency anaemia (36.87mmol/mol [5.53%]), compared to those measured in individuals without anaemia (34.75mmol/mol [5.34%] ); (p 〈 0.0001). Multiple linear regression analysis showed that haemoglobin values are inversely associated with HbA 1c levels. To the best of our knowledge, this paper is the first attempt to propose, for subjects affected by iron deficiency anaemia, a correction of HbA 1c values based on haemoglobin level after a complete blood count, which may be required when diagnosing pre‐diabetes and monitoring diabetes. Copyright © 2018 John Wiley & Sons.
Type of Medium:
Online Resource
ISSN:
2047-2897
,
2047-2900
DOI:
10.1002/pdi.2018.35.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2652246-9
