In:
physica status solidi (a), Wiley, Vol. 215, No. 22 ( 2018-11)
Abstract:
The spatial and temporal resolutions of bio‐imaging with magnetic nanoparticles (MNP) as a label and a diamond substrate as a magnetic field imager are investigated. To realize fast and accurate magnetic field imaging even for a substrate with unresolved hyperfine peaks, relative fluorescence is measured at four operation points corresponding to the steepest slopes of two dips in the ODMR spectrum. The (111) diamond substrate with a 3.5‐μm thick chemical vapor deposition film with an NV − density of 1.6 × 10 16 cm −3 allows us to detect 1‐μm MNPs scattered on its surface with an accumulated exposure time of 19 s under external DC magnetic field of 1.3 mT. Theoretical limit of temporal sensitivity is estimated to be more than four orders of magnitude smaller than measured. Although for measurement in culture medium, an objective lens with longer working distance is required and the condition will become somewhat worse, a spatiotemporal resolution of 〈 1 s and 〈 1 μm for the density and quality of the NV centers used in this study is expected if the already reported sensitivity enhancement technologies are further incorporated.
Type of Medium:
Online Resource
ISSN:
1862-6300
,
1862-6319
DOI:
10.1002/pssa.v215.22
DOI:
10.1002/pssa.201800254
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1481091-8
detail.hit.zdb_id:
208850-2