In:
Recueil des Travaux Chimiques des Pays-Bas, Wiley, Vol. 110, No. 5 ( 1991-01), p. 189-194
Kurzfassung:
Biological hydroxylation is an area with many opportunities for the production of fine chemicals. Especially for the production of hydroxylated aromatic and alicyclic compounds, the specificity and mildness of biocatalysis can be beneficial. 1,2,3,4‐Tetrahydronaphthalene (Tetralin) is a bicyclic aromatic compound, consisting of an aromatic and an alicyclic moiety. The biological oxidation of this compound provides an interesting model reaction, because different sites of initial attack are possible. Eight rains of bacteria that utilize tetralin as sole source of carbon and energy have been teed for the formation and accumulation of interesting oxidation products. Accumulation of oxidation products characteristic of both the oxidation of the aromatic and the alicyclic moiety has been demonstrated. Two rains, a Corynebacterium and an Acinetobacter have been studied in more detail. Corynebacterium C125 starts with initial attack on the aromatic ring by a dioxygenase type of enzyme resulting in the formation of a cis ‐dihydro diol that is chemically dehydrated to a phenol in an acid environment. Acinetobacter T5 starts with oxidation of the benzylic carbon atom, resulting in the formation of an alcohol, that is further oxidized via a ketone.
Materialart:
Online-Ressource
ISSN:
0165-0513
,
0165-0513
DOI:
10.1002/recl.19911100510
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1991
