In:
ChemistrySelect, Wiley, Vol. 4, No. 39 ( 2019-10-24), p. 11518-11522
Abstract:
We describe herein design, synthesis and conformational investigations of polypeptides attached on a rigid dimedone template. Two identical peptide chains are attached on a single carbon containing dimedone as a scaffold. Dimedone assists in controlling the secondary interactions through strong intramolecular helical C‐12 and C‐15 membered bifurcated hydrogen bonding on both the peptide chains along with propagating the helical architecture of the peptide chains attached. There exists a C‐6 hydrogen bonding for the single stranded peptides attached to dimedone. Extensive structural investigations involving single crystal X‐ray diffraction, solution‐state NMR and CD studies of oligopeptides have been undertaken.
Type of Medium:
Online Resource
ISSN:
2365-6549
,
2365-6549
DOI:
10.1002/slct.201903087
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2844262-3