In:
Teratogenesis, Carcinogenesis, and Mutagenesis, Wiley, Vol. 6, No. 5 ( 1986-01), p. 375-381
Abstract:
The teratogenic potential of the fungicide dinocap was evaluated in CD‐1 mice. Pregnant mice were dosed by intubation with dinocap in corn oil on gestation days 7‐16. Doses used were 0, 5, 10, 20, 40, 80, and 120 mg/kg/day, based on day 6 weight. Dams were killed on day 18, at which time fetuses were counted, weighed, and preserved for necropsy or skeletal examination. The highest dose killed 80% of the dams dosed, while 29% of the dams in the 80 mg/kg group died during dosing. There was no dose‐related maternal mortality at lower doses. Net maternal weight gain was affected only at 80 mg/kg/day. There were no live fetuses at 120 mg/kg/day. The number of live fetuses per litter was decreased and resorptions increased at 80 mg/kg. Dose‐related decreases in gravid uterus weight and fetal weight were significant at all doses of dinocap. Cleft palate was found in fetuses at 5(1/234; 0.4%), 20(46/195; 23.6%), 40(140/185; 75.5%), and 80(63/85; 74.1%) mg/kg/day. There was a dose‐related increase in supernumerary ribs and a low frequency of exencephaly and umbilical hernia at high doses. This study shows that dinocap is teratogenic in the CD‐1 mouse at doses well below those causing maternal toxicity.
Type of Medium:
Online Resource
ISSN:
0270-3211
,
1520-6866
DOI:
10.1002/tcm.1770060504
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
1474933-6
