In:
Seminars in Immunopathology, Springer Science and Business Media LLC, Vol. 43, No. 1 ( 2021-02), p. 45-64
Kurzfassung:
The thymus prevents autoimmune diseases through mechanisms that operate in the cortex and medulla, comprising positive and negative selection and the generation of regulatory T-cells (Tregs). Egress from the thymus through the perivascular space (PVS) to the blood is another possible checkpoint, as shown by some autoimmune/immunodeficiency syndromes. In polygenic autoimmune diseases, subtle thymic dysfunctions may compound genetic, hormonal and environmental cues. Here, we cover (a) tolerance-inducing cell types, whether thymic epithelial or tuft cells, or dendritic, B- or thymic myoid cells; (b) tolerance-inducing mechanisms and their failure in relation to thymic anatomic compartments, and with special emphasis on human monogenic and polygenic autoimmune diseases and the related thymic pathologies, if known; (c) polymorphisms and mutations of tolerance-related genes with an impact on positive selection (e.g. the gene encoding the thymoproteasome-specific subunit, PSMB11 ), promiscuous gene expression (e.g. AIRE , PRKDC , FEZF2 , CHD4 ), Treg development (e.g. SATB1 , FOXP3 ), T-cell migration (e.g. TAGAP ) and egress from the thymus (e.g. MTS1 , CORO1A ); (d) myasthenia gravis as the prototypic outcome of an inflamed or disordered neoplastic ‘sick thymus’.
Materialart:
Online-Ressource
ISSN:
1863-2297
,
1863-2300
DOI:
10.1007/s00281-021-00842-3
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2021
ZDB Id:
2477301-3
