In:
European Radiology, Springer Science and Business Media LLC, Vol. 33, No. 9 ( 2023-04-19), p. 6299-6307
Abstract:
In cardiac transplant recipients, non-invasive allograft surveillance for identifying patients at risk for graft failure remains challenging. The fat attenuation index (FAI) of the perivascular adipose tissue in coronary computed tomography angiography (CCTA) predicts outcomes in coronary artery disease in non-transplanted hearts; however, it has not been evaluated in cardiac transplant patients. Methods We followed 39 cardiac transplant patients with two or more CCTAs obtained between 2010 and 2021. We performed FAI measurements around the proximal 4 cm segments of the left anterior descending (LAD), right coronary artery (RCA), and left circumflex artery (LCx) using a previously validated methodology. The FAI was analyzed at a threshold of − 30 to − 190 Hounsfield units. Results FAI measurements were completed in 113 CCTAs, obtained on two same-vendor CT models. Within each CCTA, the FAI values between coronary vessels were strongly correlated (RCA and LAD R = 0.67 ( p 〈 0.0001), RCA and LCx R = 0.58 ( p 〈 0.0001), LAD and LCx R = 0.67 ( p 〈 0.0001)). The FAIs of each coronary vessel between the patient’s first and last CCTA completed at 120 kV were also correlated (RCA R = 0.73 ( p 〈 0.0001), LAD R = 0.81 ( p 〈 0.0001), LCx R = 0.55 ( p = 0.0069). Finally, a high mean FAI value of all three coronary vessels at baseline (mean ≥ − 71 HU) was predictive of cardiac mortality or re-transplantation, however, not predictive of all cause-mortality. Conclusion High baseline FAI values may identify a higher-risk cardiac transplant population; thus, FAI may support the implementation of CCTA in post-transplant surveillance. Key Point • Perivascular fat attenuation measured with coronary CT is feasible in cardiac transplant patients and may predict cardiac mortality or need for re-transplantation .
Type of Medium:
Online Resource
ISSN:
1432-1084
DOI:
10.1007/s00330-023-09614-z
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
1472718-3
