In:
Molecular Imaging and Biology, Springer Science and Business Media LLC, Vol. 23, No. 2 ( 2021-04), p. 277-286
Abstract:
PSMA imaging is frequently used for monitoring of androgen deprivation therapy (ADT) in prostate cancer. In a previous study, [ 18 F]-JK-PSMA-7 exhibited favorable properties for tumor localization after biochemical recurrence. In this retrospective study, we evaluated the performance of [ 18 F]-JK-PSMA-7 under ADT. Procedures We examined the performance of [ 18 F]-JK-PSMA-7 in 70 patients (first cohort) with increasing or detectable PSA values under ADT (PSA 〈 2 ng/ml for 21/70 patients). We further analyzed 58 independent patients with PSA levels 〈 2 ng/ml under ADT, who were imaged with [ 68 Ga]PSMA-11 or [ 18 F]DCFPyL (second cohort). Finally, we compared detection rates between [ 18 F]-JK-PSMA-7, [ 68 Ga]PSMA-11, and [ 18 F] DCFPyL. Results In the first cohort, we detected [ 18 F]-JK-PSMA-7-positive lesions in 63/70 patients. In patients with PSA levels ≥ 2 ng/ml, the detection rate was 100 % (49/49). In patients with PSA 〈 2 ng/ml, the detection rate was significantly lower (66.7 %, 14/21, p = 9.7 × 10 −5 ) and dropped from 85.7 % (12/14, PSA levels between 0.3 and 2.0 ng/ml) to 28.6 % (2/7) for PSA levels 〈 0.3 ng/ml ( p = 1.73 × 10 −2 ). In the second cohort (PSA 〈 2 ng/ml), the detection rate was 79.3 % (46/58) for [ 68 Ga]PSMA-11 or [ 18 F]DCFPyL. Again, the detection rate was significantly higher ( p = 1.1 × 10 −2 ) for patients with PSA levels between 0.3 and 2.0 ng/ml (87.0 %, 40/46) relative to those with PSA levels 〈 0.3 ng/ml (50 %, 6/12). No significant difference was found between [ 18 F]-JK-PSMA-7 and [ 68 Ga]PSMA-11 or [ 18 F]DCFPyL in patients with PSA levels 〈 2 ng/ml ( p = 0.4295). Conclusion [ 18 F]-JK-PSMA-7 PET showed a high detection rate in patients with PSA levels ≥ 0.3 ng/ml under ADT. The lower PSA threshold of 0.3 ng/ml for high detection rates was consistent across the three PSMA ligands. Thus, PSMA imaging is suitable for clinical follow-up of patients with increasing PSA levels under ADT.
Type of Medium:
Online Resource
ISSN:
1536-1632
,
1860-2002
DOI:
10.1007/s11307-020-01546-0
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2079211-6
SSG:
12
