In:
Lipids, Wiley, Vol. 45, No. 10 ( 2010-10), p. 947-962
Kurzfassung:
We recently showed that a hypocaloric carbohydrate restricted diet (CRD) had two striking effects: (1) a reduction in plasma saturated fatty acids (SFA) despite higher intake than a low fat diet, and (2) a decrease in inflammation despite a significant increase in arachidonic acid (ARA). Here we extend these findings in 8 weight stable men who were fed two 6‐week CRD (12%en carbohydrate) varying in quality of fat. One CRD emphasized SFA (CRD‐SFA, 86 g/d SFA) and the other, unsaturated fat (CRD‐UFA, 47 g SFA/d). All foods were provided to subjects. Both CRD decreased serum triacylglycerol (TAG) and insulin, and increased LDL‐C particle size. The CRD‐UFA significantly decreased plasma TAG SFA (27.48 ± 2.89 mol%) compared to baseline (31.06 ± 4.26 mol%). Plasma TAG SFA, however, remained unchanged in the CRD‐SFA (33.14 ± 3.49 mol%) despite a doubling in SFA intake. Both CRD significantly reduced plasma palmitoleic acid (16:1n‐7) indicating decreased de novo lipogenesis. CRD‐SFA significantly increased plasma phospholipid ARA content, while CRD‐UFA significantly increased EPA and DHA. Urine 8‐iso PGF 2α , a free radical‐catalyzed product of ARA, was significantly lower than baseline following CRD‐UFA (−32%). There was a significant inverse correlation between changes in urine 8‐iso PGF 2α and PL ARA on both CRD ( r = −0.82 CRD‐SFA; r = −0.62 CRD‐UFA). These findings are consistent with the concept that dietary saturated fat is efficiently metabolized in the presence of low carbohydrate, and that a CRD results in better preservation of plasma ARA.
Materialart:
Online-Ressource
ISSN:
0024-4201
,
1558-9307
DOI:
10.1007/s11745-010-3467-3
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2010
ZDB Id:
2030265-4
SSG:
12
