In:
FEBS Letters, Wiley, Vol. 231, No. 2 ( 1988-04-25), p. 385-388
Kurzfassung:
Dihydro‐leukotriene B 4 (a 5,12‐dihydroxy‐eicosatrienoic acid) has been shown to be the primary metabolite of leukotriene B 4 , (LTB 4 ) in a variety of cells other than human polymorphonuclear leukocytes (PMNLs). In this report we show that dihydro‐LTB 4 is significantly less active than LTB 4 in different biological assay systems, i.e. leukocyte chemotaxis, chemokinesis, aggregation, adhesion to endothelium and superoxide anion production. This suggests that primary reduction constitutes a second so far unknown deactivation pathway for LTB 4 .
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(88)80855-X
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1988
ZDB Id:
1460391-3
SSG:
12