In:
FEBS Letters, Wiley, Vol. 248, No. 1-2 ( 1989-05-08), p. 1-4
Kurzfassung:
The basic phospholipase A 2 (PLA 2 ) from venom of the African elapid Naja nigricollis was previously shown to have anti‐coagulant and lethal properties, both of which were abolished by treatment with p ‐bromophenacyl bromide (pBP). In the present paper we first report that pBP‐treated PLA 2 is capable of inhibiting the anti‐coagulant activity but not the lethal activity of native PLA 2 , thus suggesting that both properties might be independent. We then confirm this evidence using PLA 2 ‐specific monoclonal immunoglobulins. One of these, called HSF, neutralized the lethal activity but not the anti‐coagulant activity, whereas another antibody, called HSP2, inhibited the anti‐coagulant activity but not the lethal activity of the PLA 2 . The data presented in this paper are taken as evidence that the anti‐coagulant activity is not implicated in the lethal effects of basic PLA 2 from Naja nigricollis .
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(89)80419-3
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1989
ZDB Id:
1460391-3
SSG:
12
