In:
FEBS Letters, Wiley, Vol. 492, No. 1-2 ( 2001-03-09), p. 166-170
Kurzfassung:
Two proteins known to be involved in promoting apoptosis in mammalian cells have been identified as components of the mammalian mitochondrial ribosome. Proteolytic digestion of whole mitochondrial ribosomal subunits followed by analysis of the peptides present using liquid chromatography–tandem mass spectrometry revealed that the proapoptotic proteins, death‐associated protein 3 (DAP3) and the programmed cell death protein 9, are both components of the mitochondrial ribosome. DAP3 has motifs characteristic of guanine nucleotide binding proteins and is probably the protein that accounts for the nucleotide binding activity of mammalian mitochondrial ribosomes. The observations reported here implicate mitochondrial protein synthesis as a major component in cellular apoptotic signaling pathways.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(01)02250-5
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2001
ZDB Id:
1460391-3
SSG:
12