In:
FEBS Letters, Wiley, Vol. 511, No. 1-3 ( 2002-01-30), p. 41-45
Kurzfassung:
RANTES (regulated upon activation normal T cell expressed and secreted) is a chemoattractant cytokine important in the generation of inflammatory responses and human immunodeficiency virus resistance. In hematopoietic cells, RANTES is over‐expressed by type I interferons (IFN‐α and IFN‐β). The upstream region of the RANTES gene promoter contains a distal low affinity IFN‐stimulated response element (ISRE). Specific mutagenesis in this ISRE‐like motif abolished the activation of RANTES transcription by type I IFNs. Examination of the ISRE binding factors strongly suggested that signal transducer and activator of transcription (Stat)‐2 and p48/IFN‐stimulated gene factor 3γ (ISGF3γ) are not required for the induction of RANTES by type I IFNs. The specific requirement of Stat‐1 was demonstrated using Stat‐1‐deficient U3A cells. These results revealed a non‐classical ISRE/ISGF3 signal transduction pathway for the induction of RANTES by type I IFNs.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(01)03276-8
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2002
ZDB Id:
1460391-3
SSG:
12
