In:
FEBS Letters, Wiley, Vol. 408, No. 1 ( 1997-05-12), p. 39-42
Abstract:
Brown adipose tissue (BAT) and skeletal muscle are important sites of nonshivering thermogenesis. The uncoupling protein‐1 (UCP1) is the main effector of nonshivering thermogenesis in BAT and the recently described ubiquitous UCP2 [1] has been implicated in energy balance. In an attempt to better understand the biochemical events underlying nonshivering thermogenesis in muscle, we screened a human skeletal muscle cDNA library and isolated three clones: UCP2, UCP3 L and UCP3 S . The novel UCP3 was 57% and 73% identical to human UCP1 and UCP2, respectively, highly skeletal muscle‐specific and its expression was unaffected by cold acclimation. This new member of the UCP family is a candidate protein for the modulation of the respiratory control in skeletal muscle.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(97)00384-0
Language:
English
Publisher:
Wiley
Publication Date:
1997
detail.hit.zdb_id:
1460391-3
SSG:
12