In:
FEBS Letters, Wiley, Vol. 422, No. 2 ( 1998-01-30), p. 279-283
Kurzfassung:
We have isolated and characterized from human prostate novel splice variants of the human α 1A ‐adrenoceptor, several of which generate truncated products and one isoform, α 1A‐4 , which has the identical splice site as the three previously described isoforms. Long‐PCR on human genomic DNA showed that the α 1A‐4 exon is located between those encoding the α 1A‐1 and α 1A‐3 variants. CHO‐K1 cells stably expressing α 1A‐4 showed ligand binding properties similar to those of the other functional isoforms as well as agonist‐stimulated inositol phosphate accumulation. Quantitative PCR analyses revealed that α 1A‐4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(98)00024-6
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1998
ZDB Id:
1460391-3
SSG:
12
