In:
FEBS Letters, Wiley, Vol. 423, No. 3 ( 1998-02-27), p. 334-338
Abstract:
The receptor tyrosine kinase tie‐1 is essential for angiogenesis where it appears to have a role in vessel maturation. Here we have examined the effects of hypoxia and vascular endothelial growth factor (VEGF) on the level of tie‐1 protein expressed in bovine aortic endothelial cells. Both hypoxia (2% O 2 ) and VEGF were found to increase tie‐1 in a time‐dependent manner. Hypoxic induction was direct and effects of hypoxia and VEGF were not additive. Experiments with actinomycin D indicate that these activators regulate tie‐1 at the transcriptional level.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(98)00122-7
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
1460391-3
SSG:
12