In:
FEBS Letters, Wiley, Vol. 457, No. 3 ( 1999-09-03), p. 445-451
Abstract:
The fibronectin promoter contains an ATF/cyclic AMP (cAMP) response element (CRE) site two helical turns upstream of a CCAAT site with which it interacts. We investigated the effects of mutating these −170 CRE and −150 CCAAT elements on the promoter activity regulated by three different modulators previously known to act through CRE: ATF‐2, cAMP and E1a. While the cooperation seems to play no role in E1a action, integrity of the −150 CCAAT is necessary for ATF‐2 and cAMP efficient activation in a cell‐specific manner. These results show that the CRE and CCAAT elements function as a ‘composite element’ and establish a cell‐specific function for CRE‐CCAAT synergy.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(99)01091-1
Language:
English
Publisher:
Wiley
Publication Date:
1999
detail.hit.zdb_id:
1460391-3
SSG:
12