In:
FEBS Letters, Wiley, Vol. 584, No. 14 ( 2010-07-16), p. 3073-3079
Kurzfassung:
In this study, we observed that low glucose or fructose reduces the increase in hypoxia‐inducible factor‐1α (HIF‐1α) protein under hypoxic conditions. 6‐Aminonicotinamide (6‐AN), an inhibitor of the pentose phosphate pathway (PPP), also inhibited the increase of HIF‐1α protein under hypoxic conditions, while the reduced protein levels of HIF‐1α by low glucose were apparently recovered by the addition of MG‐132 or NADPH. Moreover, siRNA for glucose‐6‐phosphate dehydrogenase, which produces NADPH, reduced the increase in HIF‐1α protein. On the other hand, cobalt‐induced expression of HIF‐1α protein was not affected by low glucose or 6‐AN under normoxic conditions. In conclusion, glucose metabolism through the PPP, but not in glycolysis, plays an important role in the stabilization of HIF‐1α protein under hypoxic conditions.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/j.febslet.2010.05.046
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2010
ZDB Id:
1460391-3
SSG:
12