In:
Molecular Oncology, Wiley, Vol. 8, No. 2 ( 2014-03), p. 351-365
Abstract:
Combination of a human 3D lung tumor tissue model with a Boolean in silico Model. Establishment of in silico signaling network topology for personalized medicine. Significant decrease of tumor proliferation and induction of apoptosis upon in vitro treatment with tyrosine kinase inhibitors. Decreased proliferation of tumor cells in the 3D model compared to 2D conditions. Induction of invasion with EMT by TGFβ stimulation.
Type of Medium:
Online Resource
ISSN:
1574-7891
,
1878-0261
DOI:
10.1016/j.molonc.2013.11.009
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2322586-5
