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Proper genomic profiling of ( BRCA1 ‐mutated) basal‐like breast carcinomas requires prior removal of tumor infiltrating lymphocytes

Massink, Maarten P.G. ; Kooi, Irsan E. ; van Mil, Saskia E. ; [et al.]

Wiley ; 2015

In: Molecular Oncology Vol. 9, No. 4 ( 2015-04), p. 877-888

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In: Molecular Oncology, Wiley, Vol. 9, No. 4 ( 2015-04), p. 877-888

Abstract: Extreme amounts of tumor infiltrating lymphocytes are found in basal‐like breast carcinomas. Tumor infiltrating lymphocytes severely impede proper genomic profiling of tumor material. FACS analysis can sort tumor infiltrating lymphocytes from tumor cells. Identification of characteristic copy number aberrations for BRCA1‐mutated breast tumors. Genomic profiling on FACS sorted cells overcomes tumor infiltrating lymphocyte contamination.

Type of Medium: Online Resource

ISSN: 1574-7891 , 1878-0261

URL: Article

DOI: 10.1016/j.molonc.2014.12.012

Language: English

Publisher: Wiley

Publication Date: 2015

detail.hit.zdb_id: 2322586-5