In:
British Journal of Nutrition, Cambridge University Press (CUP), Vol. 125, No. 10 ( 2021-05-28), p. 1092-1100
Kurzfassung:
It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 ( sd 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 ( sd 3), post 305 ( sd 4) mmol/kg; P 〈 0·05) but remained unchanged in ISO (pre 285 ( sd 3), post 288 ( sd 3) mmol/kg; P 〉 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO ( P 〈 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 ( sd 0·9) to 16·6 ( sd 1·7) in HYPER ( P 〈 0·01), but not in ISO ( P 〉 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females ( P 〈 0·01) but not in males ( P 〉 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 ( sd 2·0), 14·1 ( sd 1·4) pmol/l; P 〈 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.
Materialart:
Online-Ressource
ISSN:
0007-1145
,
1475-2662
DOI:
10.1017/S0007114520003475
Sprache:
Englisch
Verlag:
Cambridge University Press (CUP)
Publikationsdatum:
2021
ZDB Id:
2016047-1
SSG:
12
SSG:
21
