In:
Genetical Research, Hindawi Limited, Vol. 71, No. 2 ( 1998-04), p. 119-125
Abstract:
The house mouse, Mus musculus , harbours a variable
cluster of long-range repeats in chromosome 1. As shown in previous studies, some high-copy clusters such as the MUT cluster are
cytogenetically apparent as a homogeneously staining region (HSR) and are associated with a
distortion of the Mendelian recovery ratio when transmitted by heterozygous females. The effect is caused by a decreased viability of +/+ embryos. It is compensated by
maternal or paternal MUT . In this study, a deletion derivative of MUT , MUT del , shows normal transmission ratios and no compensating capability. In this respect, MUT del behaves like a wild-type cluster. Hence, both
properties – transmission ratio distortion and compensating capability –
map to the deleted region. The deletion comprises three-quarters of the MUT HSR and does
not extend to the nearest markers adjacent to the HSR.
Type of Medium:
Online Resource
ISSN:
0016-6723
,
1469-5073
DOI:
10.1017/S0016672398003206
Language:
English
Publisher:
Hindawi Limited
Publication Date:
1998
detail.hit.zdb_id:
2412684-6
detail.hit.zdb_id:
1472156-9
SSG:
12