In:
Development and Psychopathology, Cambridge University Press (CUP), Vol. 34, No. 5 ( 2022-12), p. 1816-1826
Kurzfassung:
The DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for attention-deficit/hyperactivity disorder and neuroticism moderate associations between parent reports of their children’s environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study. Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respectively, of the variance in externalizing behavior problems (hyperactivity/inattention and conduct problems) across ages 7, 9 and 12, with no clear developmental trends. G and E predictions of emotional symptoms and peer relationship problems were weaker. A quarter (12 of 48) of our tests of GxE were nominally significant ( p = .05). Increasing the predictive power of G and E would enhance the search for GxE.
Materialart:
Online-Ressource
ISSN:
0954-5794
,
1469-2198
DOI:
10.1017/S0954579422000931
Sprache:
Englisch
Verlag:
Cambridge University Press (CUP)
Publikationsdatum:
2022
ZDB Id:
1501055-7
SSG:
5,2
