In:
CNS Spectrums, Cambridge University Press (CUP), Vol. 10, No. 1 ( 2005-01), p. 57-61
Abstract:
Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABA A ) β 2 and GABA A γ 2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABA A β 2 : NPL narrow=−0.450; NPL broad=−0.808; GABA A γ 2 : NPL narrow=0.177; NPL broad=−0.051) or bipolar disorder (GABA A β 2 : NPL narrow=0.834; NPL broad=0.783; GABA A γ 2 : NPL narrow=−0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABA A β 2 and GABA A γ 2 genes are significantly linked to major psychoses in a Portuguese population.
Type of Medium:
Online Resource
ISSN:
1092-8529
,
2165-6509
DOI:
10.1017/S1092852900009913
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2005
detail.hit.zdb_id:
2149753-9
