In:
Journal of Radiotherapy in Practice, Cambridge University Press (CUP), Vol. 11, No. 4 ( 2012-12), p. 271-273
Abstract:
We described a rare case of multiple myeloma in a 60-year-old man, in whom relapse limited to the irradiated area in the left lobe of the liver developed following radiotherapy for lesions in 11th and 12th thoracic spines. Immunohistochemical analysis revealed expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (c-Met) in the hepatocytes in the irradiated area of the liver. We speculate that the malignant plasma cells might have proliferated in response to local increase of HGF production in the irradiated liver. The role of HGF in the extraosseous spread of multiple myeloma and also under the experimental condition of hepatic transplantation is discussed.
Type of Medium:
Online Resource
ISSN:
1460-3969
,
1467-1131
DOI:
10.1017/S1460396912000131
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2012
detail.hit.zdb_id:
2194408-8