In:
International Journal for Vitamin and Nutrition Research, Hogrefe Publishing Group, Vol. 87, No. 3-4 ( 2017-05-01), p. 149-158
Abstract:
Abstract. Pomegranate juice with a high content of polyphenols, pomegranate extract, ellagic acid, and urolithin A, have anti-oxidant and anti-obesity effects in humans. Pomegranate juice extends lifespan of Drosophila melanogaster. Caenorhabditis elegans (C. elegans) (n = 6) compared to the control group in each treatment, lifespan was increased by pomegranate juice in wild type (N2, 56 %, P 〈 0.001) and daf-16 mutant (daf-16(mgDf50)I) (18 %, P = 0.00012), by pomegranate extract in N2 (28 %, P = 0.00004) and in daf-16(mgDf50)I (10 %, P 〈 0.05), or by ellagic acid (11 %, P 〈 0.05). Pomegranate juice reduced intestinal fat deposition (IFD) in C. elegans (n = 10) N2 (–68 %, P = 0.0003) or in the daf-16(mgDf50)I (–33 %, P = 0.0034). The intestinal fat deposition was increased by pomegranate extract in N2 (137 %, P 〈 0.0138) and in daf-16(mgDf50)I (26 %, P = 0.0225), by ellagic acid in N2 (66 %, P 〈 0.0001) and in daf-16(mgDf50)I (74 %, P 〈 0.0001), or by urolithin A in N2 (57 %, P = 0.0039) and in daf-16(mgDf50)I (43 %, P = 0.0001). These effects were partially mediated by the daf-16 pathway. The data may offer insights to human aging and obesity due to homology with C. elegans.
Type of Medium:
Online Resource
ISSN:
0300-9831
,
1664-2821
DOI:
10.1024/0300-9831/a000570
Language:
English
Publisher:
Hogrefe Publishing Group
Publication Date:
2017
SSG:
15,3
