In:
Zeitschrift für Neuropsychologie, Hogrefe Publishing Group, Vol. 32, No. 1 ( 2021-03-01), p. 24-29
Abstract:
Abstract. Limbic encephalitis (LE) is an encephalopathic syndrome caused by antineuronal antibodies against extracellular or intracellular neuronal structures. LE may present clinically with a variety of symptoms, including epileptic seizures, cognitive and memory deficits, and personality changes. Whereas LE mediated by antibodies against intracellular antigens is frequently of paraneoplastic origin and associated with a poorer prognosis, LE mediated by antibodies against extracellular or transmembrane antigens causes potentially reversible neuronal dysfunction and, given early diagnosis and treatment, is associated with a comparatively benign prognosis. We present and discuss four different cases of autoantibody-mediated LE, with different clinical outcomes and both with and without paraneoplastic origin. Red flags pointing to the diagnosis of antibody-mediated LE include rapidly progressing personality changes or memory deficits and disorientation, novel epileptic seizures, and a history of neoplasia.
Type of Medium:
Online Resource
ISSN:
1016-264X
,
1664-2902
DOI:
10.1024/1016-264X/a000315
Language:
German
Publisher:
Hogrefe Publishing Group
Publication Date:
2021
detail.hit.zdb_id:
2091184-1
SSG:
5,2
