In:
Zeitschrift für Psychologie, Hogrefe Publishing Group, Vol. 224, No. 2 ( 2016-04), p. 133-138
Kurzfassung:
Abstract. The ability to learn and the ability to reshape brain circuits are regarded as some of the most remarkable and important features of the brain. This ability declines with age due to largely unknown reasons, and it also is altered following stroke. Brain aging is associated with a progressive increase of the levels of inflammatory cytokine in the brain. Likewise, stroke causes pronounced increases of inflammatory cytokines in the brain. Following stroke, plasticity of the cortical representation following sensory deprivation and visualized with [ 14 C]-2-deoxyglucose autoradiography is impaired for several weeks. Likewise, plastici ty of visual acuity induced by occlusion of the ipsilateral eye is impaired. Both forms of plasticity may be rescued by treatment with anti-inflammatory drugs. In contrast to this, ocular dominance plasticity which is also induced by visual occlusion is not rescued by this intervention, neither following stroke nor in aged brains. Antiinflammatory interventions may therefore be a useful tool to enhance brain plasticity following stroke, but need to be supplemented by additional strategies to enhance brain plasticity.
Materialart:
Online-Ressource
ISSN:
2190-8370
,
2151-2604
DOI:
10.1027/2151-2604/a000247
Sprache:
Englisch
Verlag:
Hogrefe Publishing Group
Publikationsdatum:
2016
ZDB Id:
200122-6
ZDB Id:
2090996-2
SSG:
5,2
