In:
Clinical & Translational Immunology, Wiley, Vol. 4, No. 6 ( 2015-06)
Abstract:
A novel source of the cell‐killing enzyme granzyme B has been found in patients with acute infectious mononucleosis (glandular fever). The enzyme is already known to be released by T‐cells and natural killer cells of the immune system as part of the body's response to virus infection. Infectious mononucleosis is caused by infection with Epstein‐Barr virus (EBV). Joseph Trapani of the Peter MacCallum Cancer Centre in Melbourne, Australia, and co‐workers in Australia and the USA investigated the origin of granzyme B in the blood of recently diagnosed patients. The research suggests that granzyme B may be produced by B‐cells of the immune system infected with EBV. The identification of this unexpected source of the enzyme should assist understanding of infectious mononucleosis and also the role of granzyme B in virus infection in general.
Type of Medium:
Online Resource
ISSN:
2050-0068
,
2050-0068
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2694482-0